Commanders: O
83 commanders. Each has a deck guide with its most-played cards.
- O-Kagachi, Vengeful Kami
- O'aka, Traveling Merchant
- Ob Nixilis of the Black Oath
- Ob Nixilis, Captive Kingpin
- Ob Nixilis, the Ascended
- Ob Nixilis, the Fallen
- Ob Nixilis, Unshackled
- Obeka, Brute Chronologist
- Obeka, Splitter of Seconds
- Obosh, the Preypiercer
- Obuun, Mul Daya Ancestor
- Obyra, Dreaming Duelist
- Obzedat, Ghost Council
- Octavia, Living Thesis
- Odric, Blood-Cursed
- Odric, Lunarch Marshal
- Odric, Master Tactician
- Ognis, the Dragon's Lash
- Ohabi Caleria
- Óin the Brave
- Ojer Axonil, Deepest Might // Temple of Power
- Ojer Kaslem, Deepest Growth // Temple of Cultivation
- Ojer Pakpatiq, Deepest Epoch // Temple of Cyclical Time
- Ojer Taq, Deepest Foundation // Temple of Civilization
- Oji, the Exquisite Blade
- Ojutai, Soul of Winter
- Okaun, Eye of Chaos
- Oketra the True
- Okoye, Dora Milaje Leader
- Okoye, Mighty and Adored
- Old Flitterfang
- Old Gnawbone
- Old Hob, Alleycat Blues
- Old Man Willow
- Old One Eye
- Old Rutstein
- Old Stickfingers
- Olivia Voldaren
- Olivia, Crimson Bride
- Olivia, Mobilized for War
- Olivia, Opulent Outlaw
- Oloro, Ageless Ascetic
- Omarthis, Ghostfire Initiate
- Omega, Heartless Evolution
- Omnath, Locus of All
- Omnath, Locus of Creation
- Omnath, Locus of Mana
- Omnath, Locus of Rage
- Omnath, Locus of the Roil
- Omnath, Locus of the Void
- Omo, Queen of Vesuva
- Oona, Queen of the Fae
- Opal-Eye, Konda's Yojimbo
- Optimus Prime, Hero // Optimus Prime, Autobot Leader
- Orah, Skyclave Hierophant
- Orca, Siege Demon
- Orcus, Prince of Undeath
- Ori, Keeper of Songs
- Ori, Plate Stacker
- Orim, Samite Healer
- Oriss, Samite Guardian
- Ormos, Archive Keeper
- Orochi Eggwatcher // Shidako, Broodmistress
- Oroku Saki, Shredder Rising
- Oros, the Avenger
- Orthion, Hero of Lavabrink
- Orvar, the All-Form
- Orysa, Tide Choreographer
- Osgir, the Reconstructor
- Osgood, Operation Double
- Oskar, Rubbish Reclaimer
- Oswald Fiddlebender
- Otharri, Suns' Glory
- Othelm, Sigardian Outcast
- Otrimi, the Ever-Playful
- Overseer of Vault 76
- Ovika, Enigma Goliath
- Oviya Pashiri, Sage Lifecrafter
- Oviya, Automech Artisan
- Owen Grady, Raptor Trainer
- Oyobi, Who Split the Heavens
- Ozai, the Phoenix King
- Ozox, the Clattering King